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eBook Hypercholesterolemia: Clinical and Therapeutic Implications (Atherosclerosis Reviews) (Vol 18) download

by Joseph Stokes,Mario Mancini

eBook Hypercholesterolemia: Clinical and Therapeutic Implications (Atherosclerosis Reviews) (Vol 18) download ISBN: 0881674354
Author: Joseph Stokes,Mario Mancini
Publisher: Raven Pr (June 1, 1988)
Language: English
Pages: 202
ePub: 1583 kb
Fb2: 1120 kb
Rating: 4.5
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Category: Medics
Subcategory: Pharmacology

Author: Joseph Stokes, Mario Mancini.

Author: Joseph Stokes, Mario Mancini. The latter portion of the book examines the mechanisms of action of drugs used to control plasma cholesterol and presents extensive studies comparing the efficacy of HMG-CoA reductase inhibitors, cholestyramine, and probucol.

All clinical studies involving the use of HMG-CoA reductase inhibitors exclusively during childhood or adolescence were . March 1989 · International Journal of Cardiology.

All clinical studies involving the use of HMG-CoA reductase inhibitors exclusively during childhood or adolescence were evaluated. A mean low-density lipoprotein cholesterol (LDL-C) concentration reduction of 25% can be obtained in children and adolescents treated with lovastatin, pravastatin, or simvastatin along with a lipid-lowering diet. Viral hepatitis in pregnancy: Maternal and/or foetal clinical problem? January 1992.

Stokes J III, Mancini M, eds. : Clinical and Therapeutic Implications. The microscopic changes that occur in spontaneous atherosclerosis have been described by Stary18 and modified by the American Heart Association (AHA). New York: Raven Press, 1988:1–23. Oxidized LDL within the intima may play a role in the adhesion of circulating monocytes to the arterial wall. 29 Using autopsy results from the coronary arteries and aortas of young people, Stary described five distinct lesions. A Stary I lesion, not apparent macroscopically, consists of isolated macrophages or foam cells within the intima of the involved vessel.

Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque. Initially, there are generally no symptoms. When severe, it can result in coronary artery disease, stroke, peripheral artery disease, or kidney problems, depending on which arteries are affected. Symptoms, if they occur, generally do not begin until middle age.

Atherosclerosis has been derived from a Greek word, Athero meaning gruel. Marchand introduced the term atherosclerosis describing the assosciation of fatty degeneration and vessel stiffening. It’s the patchy intramural thickening of the subintima. The earliest lesion is the fatty streak.

Defects in the gene encoding the LDL receptor, which occur in patients with familial, elevate the plasma LDL level and produce premature coronary atherosclerosis

Defects in the gene encoding the LDL receptor, which occur in patients with familial, elevate the plasma LDL level and produce premature coronary atherosclerosis. The physiologically important LDL receptors are located primarily in the liver, where their number is regulated by the cholesterol content of the hepatocyte. Conversely, maneuvers that lower the cholesterol content of hepatocytes, such as ingestion of drugs that inhibit cholesterol synthesis (mevinolin or compactin) or prevent the reutilization of bile acids (cholestyramine or colestipol), stimulate LDL receptor production and lower plasma LDL levels.

2007) Phagocytosis in atherosclerosis: Molecular mechanisms and implications for plaque progression and stability. Cardiovasc Res 73:470–480PubMedGoogle Scholar. Schuchman EH (2007) The pathogenesis and treatment of acid icient Niemann–Pick disease.

This volume highlights recent progress in devising strategies for the management of hypercholesterolemia. The studies presented show that the risk of atherosclerosis in individuals with high blood cholesterol levels can be substantially reduced by a diet low in cholesterol and saturated fat, by elimination of high blood pressure and other factors that contribute to atherosclerosis, and by treatment with drugs that are highly effective in lowering plasma cholesterol. After reviewing the evidence that lipoprotein metabolism plays a central role in atherogenesis, the contributors analyze clinical trials of interventions aimed at lowering cholesterol and formulate new guidelines for lowering blood cholesterol and reducing the risk of coronary heart disease. Full consideration is also given to the significance of hypercholesterolemia as a public health problem. The latter portion of the book examines the mechanisms of action of drugs used to control plasma cholesterol and presents extensive studies comparing the efficacy of HMG-CoA reductase inhibitors, cholestyramine, and probucol.