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eBook Protective Groups in Organic Chemistry download

by J. McOmie

eBook Protective Groups in Organic Chemistry download ISBN: 0306307170
Author: J. McOmie
Publisher: Springer; 1973 edition (December 31, 1995)
Language: English
Pages: 418
ePub: 1854 kb
Fb2: 1677 kb
Rating: 4.5
Other formats: mobi mbr rtf lit
Category: Math Sciences
Subcategory: Chemistry

Protective Groups in Organic Chemistry.

Protective Groups in Organic Chemistry. price for USA in USD (gross). ISBN 978-1-4684-7218-9. At that time the five main methods for the removal of protective groups involved acid or base hydroly­ sis, reduction, oxidation, or thermal elimination reactions.

ISBN-13: 978-1468472202.

What are protective groups? A protective group (also referred to as "protecting group") is a reversably formed derivative of an existing functional group in a molecule. The protective group is temporarily attached to decrease reactivity so that the protected functional group does not react under synthetic conditions to which the molecule is subjected in one or more subsequent steps. As an example, whereas amines are nucleophiles and react with electrophiles, the amino group is no longer nucleophilic after being converted to a carbamate.

During the past decade there has been a great increase in the use of protective groups, especially in the synthesis of large and complex organic molecules

During the past decade there has been a great increase in the use of protective groups, especially in the synthesis of large and complex organic molecules. Perhaps the greatest activity has been in the peptide field where such triumphs as the total synthesis of insulin and of bovine ribonuclease (molecular weight 13,700) have been achieved.

We all know that reading Protective Groups In Organic Chemistry Mcomie J is useful, because we can get a lot of. .

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Theodora W. Greene, Peter . This book presents information on the synthetically useful protective groups (-500) for five major functional groups: -OH, -NH,-SH,-COOH, and C O. References through 1979, the best method(s) of formation and cleavage, and some information on the scope and limitations of each protective group are given. W. McOmie (E. Protective Groups in Organic Chemistry, Plenum Press, New York and London, 1973) for his interest in the project and for several exchanges of correspondence, and to Mrs. Mary Fieser, Professor Frederick D. Greene, and. ix. PREFACE.

Balaji Advanced Problems in Organic Chemistry Part 2 upto page 241 to 460 by M S Chouhan for IIT. For over half a century, this book has served the discipline of medicinal chemistry for both. 67 MB·91,830 Downloads. his father's business failed. Advanced Organic Chemistry; Reaction Mechanisms; Volume in Advanced Organic Chemistry Series. Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry. 2 MB·45,200 Downloads.

McOmie, J. F. (John Frederick William), 1920-. Download book Protective groups in organic chemistry.

Are you sure you want to remove Protective groups in organic chemistry. Organic compounds, Protective groups (Chemistry), Synthesis. There's no description for this book yet. from your list? Protective groups in organic chemistry. Published 1973 by Plenum Press in London, New York.

During the past decade there has been a great increase in the use of protective groups, especially in the synthesis of large and complex organic molecules. Perhaps the greatest activity has been in the peptide field where such triumphs as the total synthesis of insulin and of bovine ribonuclease (molecular weight 13,700) have been achieved. Correspondingly, more protective groups have been devised for the protection of amino and imino groups than for any other functional group. There are many reviews and books on the synthesis of pep tides but there has been no general survey of protective groups since my 1 own review in 1963. At that time the five main methods for the removal of protective groups involved acid or base hydroly­ sis, reduction, oxidation, or thermal elimination reactions. Recent advances include the use of photo-sensitive and metal­ ion sensitive protective groups, and the attachment of functional groups to reactive polymers as a method of protec­ tion during the solid-phase synthesis of peptides and poly­ nucleotides. Another interesting development is the design and use of protective groups with a built-in 'safety-catch', which can be 'released' by a specific chemical reaction, so that an otherwise stable bond is made labile at the appropriate moment thereby allowing the protective group to be removed under very 2 mild conditions. My own interest in protective groups dates from 1944 when, as a student, I gave two lectures on the subject and produced an 11 page review including 70 references.