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eBook Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation download

by Peter Greaves

eBook Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation download ISBN: 0444527710
Author: Peter Greaves
Publisher: Elsevier Science; 3 edition (April 6, 2007)
Language: English
Pages: 960
ePub: 1936 kb
Fb2: 1826 kb
Rating: 4.7
Other formats: mbr txt lit azw
Category: Different
Subcategory: Medicine and Health Sciences

This work covers effectively all aspects of drug-induced pathology that may be encountered within preclinical toxicity studies. It fills a gap in the pathology literature relating to the preclinical safety assessment of new medicines.

This work covers effectively all aspects of drug-induced pathology that may be encountered within preclinical toxicity studies. It systematically describes, in one volume, both spontaneous and drug induced pathology on an organ by organ basis. Information relevant to understanding the nature of pathological changes in pre-clinical studies and assessment of their relevance to the clinical investigation of new drugs is also covered

Interpretation and Relevance in Drug Safety Evaluation

Interpretation and Relevance in Drug Safety Evaluation. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines.

Chapters are organized by body system and describe specific pathologies in them

This work covers effectively all aspects of drug-induced pathology that may be encountered within preclinical toxicity studies. Information relevant to understanding the nature of pathological changes in pre-clinical studies and assessment of their relevance to the clinical investigation of new drugs is also covered

Do the pathology findings completely preclude giving a new drug safety to humans?

Even trained pathologists with expertise in toxicological pathology have to make the difficult prediction of whether any drug induced pathology in animals is likely to occur in humans  . Pathology represents a challenge for everybody involved in drug development. Do the pathology findings completely preclude giving a new drug safety to humans?

Books : Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation (Hardcover).

This work covers effectively all aspects of drug-induced pathology that may be encountered within preclinical toxicity studies. It fills a gap in the pathology literature relating to the preclinical safety assessment of new medicines. It systematically describes, in one volume, both spontaneous and drug induced pathology on an organ by organ basis. Information relevant to understanding the nature of pathological changes in pre-clinical studies and assessment of their relevance to the clinical investigation of new drugs is also covered. Numerous colour photographs are included that highlight and embellish the histopathological features that are described. It also contains many pertinent references to both human and animal pathology forming an essential basis for the assessment of drug-induced pathology. NEW TO THE THIRD EDITION:* Covers drug induced pathology in preclinical (animal) studies and their relevance for patients or volunteers in clinical studies* General comments to each chapter about the relevance of pathological findings to humans* Provides essential information that can help decide the relevance of particular lesions for patients
Comments: (2)
RUsich155
More comprehensive than the second edition and packed full of relevant information and references on clinical significance of preclinical toxicity findings
Moonworm
good.